Uh-oh. The Grasping Green Giant — aka the federal Environmental Protection Agency — may be about to pounce on New York once again.

The Post reports that the EPA has been sniffing around the Second Avenue Subway construction project on the Upper East Side — in response, it claims, to a citizen’s gripe about dust.

EPA officials inspected the site to make sure the MTA, which is overseeing construction, has proper air-quality-monitoring equipment on the premises. (It does.)

So far, so good.

The feds also demanded all of the transit agency’s air-quality data and test results from the project.

Hmm. That might be acceptable, too — as long as the agency deals with the information in good faith.

Trouble is, don’t bet that it will.

Remember, the EPA is staffed — from top down — with overzealous ideologues who crave one thing and one thing only: power.

Power to regulate and dictate — and, in effect, gum up plans for countless projects.

With costly, and sometimes deadly, consequences.

The tragically famous example of that here in New York: the Deutsche Bank building at Ground Zero.

That tower was wrecked in the 9/11 attack, but it took until this year — nearly a decade later — for workers to finish tearing it down, thanks in large part to EPA rules.

Meanwhile, amid the delays, a blaze in 2007 erupted, killing two firefighters who were trapped by plywood and plastic sheeting that the agency had ordered to contain supposed toxins — every last molecule of them.

Never mind that there was never any evidence that those “toxins” posed any significant danger to anyone.

Other local EPA power grabs?

l The agency has insisted that the city spend hundreds of millions of dollars (which surely could be better used to educate kids) to replace schoolhouse light bulbs containing PCBs — without any proof that the bulbs are at all dangerous.

l It KO’d the city’s plans for cleaning up the Gowanus Canal, causing delays — and discouraging investment.

l It ordered GE to spend a fortune dredging the Hudson for even more PCBs — though that meant the “harmful” substance would be stirred back into the water.

At the national level, glomming power is practically EPA’s mission statement.

Its rules on factory and power-plant emissions are sure to impose hidden taxes on everyone — and kill jobs.

For the Upper East Side, though, the main worry should be EPA-triggered delays, should the agency discover a few suspect molecules of something in the vicinity of the subway project.

Residents might well want to think twice before filing complaints.

Unless, of course, they long to see the subway project dragged out — forever.