An Upper East Side townhouse where former First Lady Eleanor Roosevelt once lived and entertained world leaders – from Nikita Khrushchev to Golda Meir to John F. Kennedy – is about to hit the market for $20 million.

The listing was first reported by the Wall Street Journal.

Roosevelt also penned her popular six-day-a-week newspaper column, “My Day,” from the townhouse at 55 E. 74th St., where she lived from 1959 until she died in 1962.

The home is where Khrushchev dropped by during his infamous shoe-pounding UN General Assembly visit in 1960. It’s also where she hosted a champagne-fueled election night watching party in 1960, the year she was an unofficial consultant to the then-candidate and future president, JFK.

The longest-serving First Lady, who was the first US delegate to the United Nations, wrote her column from 1935 until 1962.

She co-owned the home with dear friends David and Edna Gurewitsch, who lived on the top floors while she took the bottom ones.

The current seller is nonprofit founder Meera Gandhi, who converted it into a single-family home and raised three children there. She is downsizing now that her kids are grown up. Gandhi has a collection of Eleanor Roosevelt memorabilia that will be sold with the house.

The five-story limestone townhouse, built in 1898, comes with six bedrooms and a back garden. It is one of eight limestone townhouses, with iron-grille doors, built around 1898 by architects Buchman and Deisler from 47 to 59 E. 74th St.

The home features a marble floor and a curved staircase in the entry hall. There’s also a chef’s kitchen that opens to a media room with 10-foot-long skylights and doors that lead to a rear garden, according to a former listing, while a rear staircase leads to a serving kitchen, a formal dining room with tall ceilings and a marble fireplace.