“Grey’s Anatomy” is the longest-running medical drama of all time, with its 15 seasons in the books and at least two more on the way. The show certainly has staying power.

But the Hamptons home of star Ellen Pompeo?

Not so much. Pompeo is trying once again to sell her stunning farmhouse-style home, at 1645 Millstone Road in Sag Harbor, for $3.5 million. (In 2018, Pompeo listed it for $3.79 million with another brokerage, as Gimme Shelter exclusively reported at the time.)

Pompeo built the home in 2013 after buying the 8.38-acre property for $925,000 in 2011 as a tear-down.

The resulting 2,400-square-foot, three-story spread features five bedrooms (with one doubling as a media room/bar) and four bathrooms.

The main-floor master suite has a private staircase leading to an en suite guest room.

There’s also a roomy eat-in kitchen and an open living room with high ceilings, glass walls and a fireplace.

The second fireplace is located in the glassed-in dining porch, which overlooks a pool and lawns.

There’s also room for a tennis court.

The listing brokers are Corcoran’s Cee Scott Brown and Jack Pearson.