The first late scratch in the opening college football weekend is a significant one.

Lane Kiffin has a breakthrough case of COVID-19 and will miss Ole Miss’ season opener Monday against Louisville.

In a statement on Saturday, the Rebels head coach said he is “grateful to be vaccinated” and experiencing mild symptoms after he was hesitant initially about getting the jab.

“I’m proud of our program’s commitment to vaccination, and as a result, there are currently no other cases to report or team members expected to miss the game,” Kiffin said.

Kiffin, in his second year with the school, has said the Rebels’ team has reached 100% vaccination. Ole Miss plays in a state that is 38% fully vaccinated, among the worst in the nation.

Kiffin appeared on ESPN’s “College GameDay” and said he had tested positive for the coronavirus about two days ago. He was disappointed — “didn’t go anywhere but the office and home,” he said — but greatly relieved no one, including quarterback Matt Corral, whom he is around often, has to sit out as a close contact because everyone is vaccinated.

Ole Miss said it is not sure yet who will handle the head-coaching duties against Louisville in Atlanta.