PITTSBURGH — The buzzer blared again.

For the second time in the first half, Villanova failed to beat the shot clock, engulfing one of the friendliest coaches in college basketball in fury.

As the players headed to the sideline for a TV timeout, Jay Wright stomped onto the court, and screamed:

“Wake the f— up!”

Mikal Bridges and Donte DiVincenzo then made sure some No. 1 seeds still act like they’re supposed to.

Following three second-round exits from the NCAA Tournament in the past four years, No. 1 Villanova displayed the dominance and poise of its 2016 national champions, and reached the Sweet 16 by crushing No. 9 Alabama with an 18-1 run to start the second half, and securing an 81-58 win Saturday at PPG Paints Arena.

Villanova (32-4), which next plays the winner of No. 5 West Virginia/No. 13 Marshall in Boston, hit 17-of-41 3-pointers, with Bridges scoring 22 of his 23 points after halftime, and DiVincenzo also hitting five 3-pointers, with five assists.

“When you play a 1-16 game, it’s not the same intensity as when you play an 8-1 game or 9-1 game, and the team you play against played in that kind of game,” said Wright, explaining the slow start. “We’ve learned that over the years … all of a sudden you get smacked in the mouth with physicality that that first game didn’t have, and I thought that was part of it. I’m trying to just get our guys going. Come on, we got to wake up. This is what it’s going to be. I thought it took us a little bit of time.”

Alabama (20-16) led for just 22 seconds of its first second round game in 12 years — freshman Collin Sexton (17 points) was the lone player to score in double-figures — but fumbled an early opportunity to put pressure on the double-digit favorite.

National Player of the Year candidate Jalen Brunson had just four points in a foul-plagued first half. Omari Spellman was stuck to the bench after picking up two fouls in a five-second span. Bridges, a likely lottery pick, missed his first five shots.

But Alabama couldn’t stop the Big East’s best bench player.

DiVincenzo, the sixth man who had been held to single-digit scoring in the past four games, carried the Wildcats in the first half, surpassing his scoring average by scoring 15 of the team’s final 20 points to give Villanova a 32-27 halftime lead.

“[It was] just more responsibility to make the right play,” DiVincenzo said. “I just found myself hot.”

The near-stalemate then took the shape of a basketball power against a football school.

After failing to make a field goal in the first half, Bridges hit four 3-pointers, and scored 19 of Villanova’s first 21 points in the second half, as the Wildcats hit their first six shots from outside.

“He’s a confident kid,” Wright said. “He used to be too nice where, ‘OK, I’m not making shots. I’m not going to shoot anymore. I’ll let everybody else do it. I will defend and rebound.’ You got to let him know, we need you to stay aggressive.”

It was the seventh time this season that the Wildcats hit at least 16 3-pointers in game.

“Some nights, we’re going to have them,” Wright said. “Some nights we’re going to have to sleep in the streets.”

And some days, a title favorite demonstrates why.