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This is sobering news.

Drinking alcohol can reduce the effectiveness of COVID-19 vaccines, according to UK experts.

In a new BBC documentary set to air Wednesday, medics evaluated changes to the immune system caused by boozing, Metro UK said.

They found that even three glasses of Prosecco halved the levels of white blood cells like lymphocytes that are crucial in creating antibodies to attack viruses, the report said.

“You need to have your immune system working tip-top to have a good response to the vaccine, so if you’re drinking the night before, or shortly afterward, that’s not going to help,” University of Manchester professor Sheena Cruickshank told the paper.

Cruickshank advised people to avoid drinking in the days around getting vaccinated.

Meanwhile, in vodka-loving Russia, officials have been even stricter — telling citizens to avoid booze for two months after getting jabbed.