The husband of Colorado mom Suzanne Morphew was arrested and charged with killing his wife more than five years after her sudden and mysterious disappearance, prosecutors announced.

Barry Morphew, 56, was taken into custody in Gilbert, Arizona, on Friday after a grand jury indicted him on a first-degree murder charge in the death of his 49-year-old wife, who was last seen on May 10, 2020, according to the Twelfth Judicial District Attorney’s Office.

“Federal, State and local law enforcement have never stopped working toward justice for Suzanne.” District Attorney Anne Kelly said in a statement.

“The Twelfth Judicial District Attorney’s Office stands in solidarity with Suzanne’s family and the citizens of Chaffee and Saguache Counties in pursuing the Grand Jury’s indictment.”

Charging documents alleged that Barry killed Suzanne on the morning of May 9, 2020, after an autopsy revealed traces of a powerful animal tranquilizer — which the suspected husband used to hunt deer — in her body.

Records showed that Barry last obtained a prescription for the tranquilizer butorphanol-azaperone-medetomidine (BAM) in March 2018, according to the indictment. 

Additionally, no individual or business in the Colorado area where the Morphews lived — and where Suzanne’s remains were later discovered — had obtained a BAM prescription between 2017 and 2020. 

“Ultimately, the prescription records show that when Suzanne Morphew disappeared, only one private citizen living in that entire area of the state had access to BAM: Barry Morphew,” the indictment stated. 

Investigators also discovered a tranquilizer needle cap, darts and a tranquilizer gun inside the couple’s home shortly after Suzanne disappeared. 

“Yet again, the government allows their predetermined conclusion to lead their search for evidence,” Barry’s attorney, David Beller, said in a statement to ABC News Friday. 

“Barry maintains his innocence. The case has not changed, and the outcome will not either.”

Suzanne never returned to their Salida home after taking a Mother’s Day bike ride, while her husband was reportedly out of town on a business trip. 

Her remains were discovered three years later during a search in Moffat, a town about 45 miles south of the Maysville home she shared with her husband and two daughters.

Barry, who has consistently maintained his innocence, was initially charged in May 2021 with his wife’s presumed death after quickly emerging as the prime suspect.

However, a judge granted the prosecutors’ motion to dismiss the case “without prejudice,” allowing them to potentially file new charges against him in the future. 

Barry, who refused to take a polygraph test after a neighbor reported his wife missing, later filed a $15 million lawsuit against prosecutors and investigators, accusing them of violating his constitutional rights. 

The couple’s daughters — Macy and Mallory — have remained by their father’s side, insisting through the years they “never had a shred of doubt” about his innocence, despite evidence that Barry and his wife’s 25-year marriage was on the rocks. 

The slain mother complained about the failing relationship in text messages to her best friend just months before she disappeared, describing Barry as a possessive and “narcissistic” man who was trying to turn their daughters against her. 

Suzanne also suspected her husband of having an affair — and she was involved in a long-distance fling with a former high school flame, whom she reportedly intended to leave Barry for. 

But Barry, who is now being held on a $3 million bond, previously claimed the two “had a wonderful life” and a “wonderful marriage.”

Prosecutors are working to extradite the accused killer back to the San Luis Valley.