A devastated Chicago store owner said he may have to close for good — after looters trashed his business for the second time in months.

Walid Mouhammad told WLS how his convenience store was targeted again just 40 days after a $300,000 restoration because it was trashed at the end of May by thugs claiming to be protesting George Floyd’s death.

The store was hit again Monday while Mouhammad was watching in real-time on security cameras as the robbers ripped out a pricey new steel security door, then trashed the store and even ripped out an ATM, he said.

Mouhammad said he and the building’s owners and staff repeatedly called for police help — but none came as the force was overwhelmed by marauders across the city.

“This is the second time,” Mouhammad told the station. “I’ve been open for just 40 days, so who will be responsible for this?”

Mouhammad said the damage is worse than the May attack, and he fears that after spending so much repairing that damage, just to see it destroyed again will likely force him to close down for good.

That would be particularly alarming for locals during the pandemic, especially the elderly who rely on his store for fresh produce and meat and would now need to travel for vital supplies, residents said.

The latest looting was sparked by the police shooting of Latrell Allen, 20, on Sunday — but cops only fired after he repeatedly shot at them while trying to flee arrest, the police department has said.

Allen is being held on $1 million bond on two counts of first-degree attempted murder and one count of unlawful possession of a weapon.