A slew of high-profile women — including New York first lady Chirlane McCray — vowed to boycott Twitter on Friday over the suspension from the site of actress and Harvey Weinstein accuser Rose McGowan.

#WomenBoycottTwitter became the top-trending hashtag on the site Thursday night with the likes of Alyssa Milano, Chrissy Teigen, Kathy Griffin — and even male stars like Mark Ruffalo — saying they’d steer clear of the app for one day.

McGowan, a key figure in the burgeoning Weinstein sexual harassment scandal, was locked out of Twitter for about 12 hours late Wednesday into Thursday.

“There are powerful forces at work,” McGowan wrote on Instagram, alleging that she was being silenced for her activism.

Twitter insisted she was booted temporarily for publishing a private phone number among a large number of tweets criticizing Weinstein and anyone who was not critical of him.

Still, the brief ban didn’t sit well with McGowan’s backers, who complain that many trolls are allowed to make abusive comments to women on the social media site without incurring similar bans.

“Tomorrow (Friday the 13th) will be the first day in over 10 years that I won’t tweet. Join me,” Milano tweeted.

Twitter reportedly has 328 million users.