Hurricane Irma shifted its deadly course toward Florida’s west coast Saturday morning after slamming into Cuba as a Category 5 storm overnight.

The most powerful Atlantic storm in a decade now has Fort Myers and Naples — and cities as far north as Sarasota and Tampa — square in its sights, forecasters said.

Experts warned the whipping 130 miles per hour winds have gained so much momentum they could still reach both coasts.

Irma is “an extremely dangerous major hurricane, and will bring life-threatening wind impacts to much of the state regardless of the exact track of the center,” according to the National Hurricane Center.

After the storm pounded northern Cuba Saturday morning – and left 22 people dead in the Caribbean – it was downgraded to Category 3, but is expected to pick up steam as it heads northwest.

Experts predict the storm will begin to veer north late Saturday, hit the Florida Keys Sunday morning and then the southwest coast of Florida by Sunday afternoon.

A total of 5.6 million people, equivalent to 25 percent of the state’s population, were ordered to evacuate Florida, according to the Florida Division of Emergency Management.

Some residents are choosing to stay put.

“All I can do is have faith we will survive this,” said Tampa nurse Renee Silverman, who lives in Tampa who is choosing not to evacuate. “My biggest fear is how long it may take to reunite with my family after it’s over.”

Irma remained 225 miles south of Miami Saturday morning, but the outer bands of the storm have already begun lashing the area with heavy rain and forceful wind gusts.

Massive power outages have already begun sweeping across the state with more than 25,015 without in the Miami area so far, according to Miami 7 News.

Additional reporting by Laurie Mizrahi