The leader of ISIS in Syria, one of the top five leaders of the global terror group, was killed and another senior jihadist injured in an airstrike, the US military said Tuesday.

Maher al-Agal was killed outside Jindayris, a city in northwest Syria near the Turkey border, US Central Command said.

A senior ISIS leader with Agal was “seriously injured” in the strike, the military said in a statement.  

“Extensive planning went into this operation to ensure its successful execution. An initial review indicates there were no civilian casualties,” the release said.

The US said Agal was responsible for developing ISIS networks outside Iraq and Syria.

“This strike reaffirms CENTCOM’s steadfast commitment to the region and the enduring defeat of ISIS,” said Col. Joe Buccino, a spokesperson for Central Command. “The removal of these ISIS leaders will disrupt the terrorist organization’s ability to further plot and carry out global attacks.”

President Biden said in a statement that the military strike took a “key terrorist off the field and significantly degrades the ability of ISIS to plan, resource, and conduct their operations in the region.”

“It sends a powerful message to all terrorists who threaten our homeland and our interests around the world. The United States will be relentless in its efforts to bring you to justice,” the president added.

“The American people — and our allies and partners — are safer today because of their actions,” Biden concluded. 

The Syrian Observatory for Human Rights, which monitors the Middle Eastern country’s ongoing civil war, said its sources reported a drone attack on two people riding a motorcycle in a village near Jindayris. The association said Agal was a prominent commander of ISIS in Raqqa before heading north to align with a Turkish-backed faction.

It also noted that Agal was the brother of Fayez al-Akal, who was killed in a similar drone attack near al-Bab, Syria, in June 2020.

ISIS, which once controlled large swaths of Syria and Iraq, has been reduced to conducting guerrilla attacks since its territorial control collapsed in 2019 following the death of Abu Bakr al-Baghdadi during a raid by US special forces in Syria. 

The US has about 900 troops in Syria serving in a largely advisory role for Syrian Democratic Forces fighting the terror group.