A 46-year-old motorcyclist died Tuesday morning after a hit-and-run in Harlem, cops say.

The biker was heading east down East 112th Street around 10:15 a.m. when he crossed 2nd Avenue and was struck by another vehicle heading south, cops said.

The 46-year-old, whose name was not released, was thrown from the bike and rushed to the Metropolitan Hospital, but he could not be saved.

The vehicle that struck the biker took off and was found abandoned a block away, police said.

No arrests have been made as of Tuesday afternoon.