The accused Upper East Side madam won’t roll over on a friend.

“They have an agenda to get me to talk about a certain person,” Anna Gristina told Dr. Phil in an interview that aired yesterday.

“I’m not going to hurt someone with a family. I’m not going to put the nail in the coffin of someone who is very dear to me.”

Gristina didn’t divulge the name of her pal to the daytime-talk doc.

Sources said prosecutors — who have claimed Gristina ran a multimillion-dollar call-girl ring and boasted of ties to law enforcement and some of the city’s biggest movers and shakers — have abandoned a bid for big names and set their sights on a single individual.

The person they want her to rat out is wealthy but hardly famous — especially compared to the well-known, politically and socially connected names about whom investigators demanded Gristina cough up information when they first arrested her last spring on a single charge of promoting prostitution.

“I have a deep sense of loyalty . . . it was the way I was raised,” Gristina said.

“Your word is everything.”

Gristina spent five months at Rikers, unable to post a sky-high $2 million bail. She won a bail reduction and has been free, with an ankle-monitor, since June, awaiting an October trial.

During the interview, she again insisted she was running a high-end matchmaking service and not a prostitution ring.

Gristina’s alleged co-madam, Jaynie Mae Baker, and two alleged hookers have all cut deals with prosecutors.