A Big Apple entrepreneur shelled out big bucks to her overbearing beau’s family in the months before her suicide — and they should pay it all back, her sister charges.

Titi Branch, who co-founded Miss Jessie’s hair products with her sister, Miko, was duped by a manipulative man deep in debt who leeched off Titi’s wealth, Miko Branch charges in Manhattan court papers.

In the two years she dated Anthony Spadafora, court papers allege, the doomed woman paid $2,000 for his mom’s psychotherapy, $35,000 in student loans for his son and $25,000 for his mom and aunt each — more than $900,000 in all, court papers allege.

Branch, 45, hung herself — but not before she changed the beneficiary of a $2 million life-insurance policy to Spadafora.

Miko says the Pennsylvania man took advantage of her sister’s depression.

Spadafora denies the allegations and says Titi just loved him.