A enraged man stabbed his wife to death yesterday in University Heights, cops said.

The 38-year-old victim was in an argument with her husband around 5:55 a.m. inside of a building on Grand Concourse near East 182nd Street when he charged at her with a knife, police said.

He stabbed the woman several times in the chest and fled the scene, sources said.

The victim was rushed to St. Barnabus where she died.