Straphangers in three tony Brooklyn neighborhoods are about to get derailed — again.

Service cuts along the F line are slated for Park Slope, Windsor Terrace and Kensington starting this weekend — and will last at least through the year.

The changes — to make way for construction at the Smith-Ninth Street stop, the highest elevated station in the city — come after the line has already gone through a series of shutdowns for several weekends in 2010. The $179 million project involves work on signals and switches, along with renovations that could eventually make way for a long-awaited F express.

Riders won’t have service from Church Avenue to Jay Street this weekend.

Then, beginning at 5 a.m. Monday and lasting through May, there will be no Manhattan-bound F or Queens-bound G at the 15th Street-Prospect Park and the Fort Hamilton Parkway stops.