Columbia University has shut down a major brain research lab on its campus after the Food and Drug Administration launched an investigation of the facility, officials said.

Work has stopped at the Kreitchman PET Center — which did research on mental illness — after federal probers found FDA violations stretching over a 4-year period.

David I. Hirsh, Columbia’s executive vice president of research, last night confirmed the probe and the closure, saying there were “shortcomings of quality control in the manufacturing process and record-keeping” at the lab.