New York will finally adopt new federal indoor mask guidelines that say those vaccinated against COVID-19 can ditch face coverings, Gov. Andrew Cuomo said Monday — after refusing to green-light them last week.

Vaccinated New Yorkers will be clear to go mask-free in most indoor settings beginning Wednesday, Cuomo announced at a press conference.

“We have to reopen smart. We have to reopen with a cautious eye, but we have to get back to life,” he said. “Effective this Wednesday, we’re going to adopt the CDC’s new guidance and regulations on masks and social distancing for vaccinated people.”

Vaccinated New Yorkers will be able to go mask-free at restaurants, retail stores, offices, gyms and salons if the business allows it.

People attending indoor events of 250 people or less can also scrap masks with permission from the venue. At larger-scale events, including sports games and concerts, attendees can go mask-free in designated sections for people who have received their shots, Cuomo said.

The new rule won’t apply on public transportation or at schools or nursing homes, where people will still be required to mask up, he said.

Face covers will also be required at homeless shelters and jails — and in city buildings and at City Hall, Mayor de Blasio said.

Private businesses and event spaces can still set their own restrictions.

Major retailers such as Starbucks, Walmart and Trader Joes have already said they will no longer require vaccinated customers to wear masks indoors unless required by local laws. Target and CVS Pharmacy also changed store policy Monday.

The Centers for Disease Control and Prevention gave the go-ahead Thursday for fully vaccinated Americans to go mask-free inside under most circumstances

But Cuomo and New York Mayor Bill de Blasio initially balked at approving the guidelines, saying they would “review” them.

The delay had sparked confusion among New Yorkers, who weren’t clear on what advice to follow inside businesses, including gyms and restaurants. 

Over the weekend, six county executives from around the state demanded Cuomo adopt the guidance. 

By Monday, he was singing a very different tune.  

“The whole point of the CDC’s change, the whole point of our change is to say to people: There are benefits to being vaccinated,” he said.

“For our part, we’re adopting the CDC and we’re saying, let’s open. This comes at a good time for New York, because we had already said we were going to do our major reopening this Wednesday.”

Earlier in the day, de Blasio also changed his stance, calling the new rules “balanced.”

“I like the guidance. I think it makes sense. It focuses on folks who are vaccinated and are going to have more freedom. That’s a tremendously positive helpful message,” he said at his own press briefing. “I think it’s balanced.”

He added, “Now we’re going to watch carefully … We’re going to watch the data. If we think something needs to be adjusted, we’ll say it.”

Some New Yorkers on Monday cheered the new mask-free indoor rule, saying it may jumpstart the Big Apple’s economy.

“We were all waiting for that announcement — 110 percent! This will be amazing for our business!” said Antorne McLeod, 33, who works at the remodeling firm Knock Out Renovations in Midtown.

He’s looking forward to some old-fashioned face time with customers — instead of trying to make sales over Zoom.

“Virtual doesn’t work…Foot traffic is our game. I’m so looking forward to people coming in, feeling samples, building a rapport. Our presentations are in person, that’s how this business works. I’m so excited!”

But others weren’t quite ready to shed their face covers indoors.

“I’m still going to have to wear it when I’m with my 8-year-old. Kids still have to wear them so she’ll be looking at me like, ‘Why do I have to wear it if you don’t?,’” Erika Berrios, a 41-year-old mother of three from Brooklyn.