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Gov. Andrew Cuomo on Wednesday accused Staten Island officials of flouting coronavirus safety guidelines — saying they are killing their neighbors with bad advice.

Cuomo said Staten Islanders comprised just 5 percent of the city’s population but now accounted for 25 percent of its COVID-19 fatalities over the past month.

The governor said the “disturbing situation” was the result of disastrous decisions regarding government guidance on mask-wearing and social distancing.

“Some elected officials in Staten Island said, ‘Well, we’re not gonna follow it. Freedom! Freedom!’” Cuomo said.

“Let me tell you what their advice has done for Staten Island, OK? Staten Island went from the lowest death rate in New York City. It now has the highest death rate.”

He added: “Staten Island has a 40 percent higher death rate than The Bronx, than Brooklyn, Queens or Manhattan … More people are dying on Staten Island. That’s what this movement on Staten Island has done.”

Cuomo’s office later released statistics showing that over the past month, Staten Island has been averaging 3.2 deaths a day, nearly one-quarter of the city’s daily average of 13.

In addition, the statistics show that Staten Island’s death rate was 14 percent, compared to 10 percent in The Bronx and Manhattan, 9 percent in Queens and 7 percent in Brooklyn.

Cuomo didn’t single out any Staten Island officials by name, but City Councilman Joe Borelli (R-Staten Island) made a public show of hosting an 11-person Thanksgiving dinner in defiance of Cuomo’s 10-person limit in “orange zone” areas.

Borelli even tweeted a “Happy Thanksgiving” photo of himself holding a drink in front of a window sticker that showed Cuomo peeping through his living-room window.

“It goes to show that the governor has become a cartoon,” Borelli told The Post the following day.

“With his absurd and arbitrary edicts, people are tuning him out.”

On Wednesday, Borelli said, “The governor has his numbers, but the south shore of Staten Island has nearly the lowest per capita death rate in the city per the health department, and our seven-day average is about 12 percent of city deaths.”

“If he had picked another day to cherry-pick, say Nov. 1, Brooklyn would show to have had 60 percent of all deaths,” he added.

“That said, people should still take all of the core precautions: wear a mask, get tested, self-quarantine if you’re symptomatic.”

Also during Wednesday’s briefing, Cuomo warned that New Yorkers would face “tremendous” tax increases — along with “massive” layoffs and borrowing — if the federal government doesn’t fill a 20 percent budget gap he blamed on the pandemic.

“This state paid the price for COVID that no other state paid,” he said.

“It’s in the nation’s best interest to get the economy going … If you starve every state, you hurt the nation.”