Gov. Andrew Cuomo said Friday “I have no reason to believe” that Amazon will change its mind about coming to Queens, explaining that a full-page ad taken out by supporters of the company was also intended to let other businesses know New York is still “open for business.”

Despite his gloomy assessment, the governor said he’s still hopeful Amazon will do an about-face and guaranteed that “I will get the state approval done” if it does.

“They’ve given no indication that they would reconsider. I think the point is not that Amazon is going to change its mind. I don’t think they do,” Cuomo said on WNYC radio.

Asked about opponents in the state Senate who helped scare away the online retail giant, Cuomo dismissed them as meaningless.

“At this point they are irrelevant,” he said. “There are other ways for the state to get this done.”

Cuomo’s comments come on the same day the New York Times published a full-page ad with an open letter to Amazon CEO Jeff Bezos signed by 78 business, labor and civic leaders that says, “A clear majority of New Yorkers support this project and were disappointed by your decision not to proceed.”

Cuomo admitted Amazon’s decision on Feb. 14 to withdraw from Long Island City was a “tremendous loss” and “national story” — in other words, a national embarrassment for the governor and New York.

He blamed the Amazon defeat on “local, petty politics” and “distortions” spurred by a “small, vocal minority.”

“We don’t operate this way. This was a mistake. This was a blunder,” Cuomo said.

“We want young people coming here and the talent. And New York is open for business. … We are the commerce capital of the country.”

Asked why he’s still wooing Amazon despite the dim prospects, he said, “I’m hired to fight for the state of New York. It’s a blow to the state.”

“The bell hasn’t sounded,” he said, adding, “Please don’t be confused. We’re open for business. If we don’t get new business, good night. That’s how our state survives.”