The federal probe of state Senate GOP Majority Leader Dean Skelos throws a potential monkey wrench into the final leg of the legislative session, when Albany grapples with numerous issues important to the city, insiders said Friday.

Among the issues: renewal of rent-control laws, real-estate tax breaks, mayoral control of schools, raising the charter-school cap, education tax credits to parochial schools, and criminal-justice reforms.

“It’s unlikely that much gets done this session,” one upstate senator said. “Too much uncertainty.”

When they return from a two-week holiday recess on Monday, lawmakers will be more focused on the investigation of Skelos and his son, Adam, than on end-of-session legislation, the senator said.

A Skelos insider insisted legislative business won’t be impacted.

“This is not going to distract him,” the source said.