A drone operated by a hotel guest crashed into Midtown’s Hilton Hotel early Friday — leaving debris behind that prompted a shutdown of the block, law enforcement sources said.

The 36-year-old hotel patron was flying the drone around 3 a.m. when it struck the hotel on Sixth Avenue near West 53rd Street, the sources said.

The guest called 911 around 10 a.m. and admitted that he was illegally operating a drone and tried to retrieve it “due to the inclement weather,” cops and sources said. 

As he did that, the drone slammed into the edge of the building, he reported to cops.

Police responded and blocked off the street because of debris, the sources said. Luckily, no one was hurt, authorities said.

The alleged drone flier was issued a summons, but not formally arrested, cops said. His name was not officially released by the NYPD.

Sandra Murray, who works at an AT&T store across from the hotel, watched late Friday morning as a fire truck responded to the scene and firemen stood on a ladder trying to bring down the device. 

Initially Murray said she thought nothing of it. 

“I’ve lived in New York my whole life so I’ve seen a lot of things,” Murray said. “I just wanted to know what they were doing.”

The drone strike happened the same day Luigi Mangione, 26, accused of fatally shooting UnitedHealthcare CEO Brian Thompson outside the same Midtown hotel in December, was set to appear in state court.

The drone incident was not related to that court proceeding, sources said.