One of New York City Mayor Eric Adams’ top lieutenants abruptly resigned from office over the weekend.

Ingrid Martin-Lewis confirmed the resignation Sunday, telling The Post she was retiring.

Her resignation – which was first reported by Politico — is effective immediately, and comes a month earlier than she was expected to leave office.

Martin-Lewis is one of several of Adams’ aides who were raided by the Manhattan District Attorney’s office this year, with her cellphone being seized by investigators in September as part of a federal subpoena to testify as a witness in a corruption case against Adams.

Despite being a longtime and fiery ally of Adams’, the two have reportedly been on the outs for several months, according to sources.

Another source said Martin-Lewis “was in real trouble” as the Manhattan District Attorney’s Office is looking into her role in city contracts, suggesting an indictment could be on the horizon.

After the first raids and investigations into Adams’ staffers – including Winnie Greco, Tim Pearson, and former police commissioner Eddie Caban — the mayor hoped to allow them to resign rather than fire them. But the process took months in some cases and the administration was forced to sack them.

Martin-Lewis fought to keep them onboard, even as people like her close pal Greco – whose dealings with foreign entities are the focus of the investigation — had been advised multiple times “not to mix personal and professional,” another source close to the matter said.

The top advisor was the one responsible for bringing Greco, Pearson and Caban on board – slipping them through the usual vetting process — and only allowed them to be fired when she was left with no choice, according to the sources.

“She protected them to the end,” the source said.

Since Adams himself was indicted on charges that he accepted illegal donations and freebies from wealthy foreigners — including Turkish officials — Martin-Lewis has reportedly been on a list of staffers New York Gov. Kathy Hochul demanded he remove from his administration.

Martin-Lewis and Adams have been close allies and friends for years.

After her resignation over the weekend, the mayor voiced support for Martin-Lewis, calling her a “friend, a confidant, and trusted advisor, but also a sister.”

“We’ve always talked about when this day would come, and while we’ve long planned for it, it is still hard to know that Ingrid won’t be right next door every day,” Hizzoner said in a statement.

“I, and every New Yorker, owe her a debt of gratitude for her decades of service to our city. While she gets to spend a lot more time with her granddaughter, I know Ingrid will still stay involved in moving our city forward from the sidelines as she continues to root for our administration and our city.”

Lewis-Martin thanked Adams for their 20 years working together, and thanked God for her 35-year career with the city.

“While I previously announced my retirement, this is still a bittersweet moment for me as government has been my life’s work,” she said in a statement.

“Now, today, the time has come for me to focus on my wonderful family and myself and retire.”