One of Pedro Espada’s most fervent supporters has finally said enough is enough.

For 15 years, Monica Harris-Coleman was an Espada family friend who worked on the former state Senate majority leader’s staff and eventually became board chairwoman of his Soundview Healthcare Services.

But within days of Espada’s conviction for embezzling half a million dollars from the nonprofit, Harris-Coleman assembled Soundview’s board to announce that she wanted Espada and sons Pedro Gautier and Alejandro to quit the clinic.

“I wanted their resignation,” Harris-Coleman told The Post.

Last month, Soundview was running out of money, unable to provide a wide range of basic medical services, and was forced to turn away a number of people seeking treatment after being cut off from Medicaid reimbursement.

“The changing of the tide for me happened when I saw what was happening to the patients. It made me sick to my stomach,” Harris-Coleman said.

Late last week — in what she views as an act of retribution — the members voted her off the board.