Gov. Andrew Cuomo’s top aide — who played a key role in trying to suppress his spiraling sexual harassment scandal — is a “ruthless, heartless, evil human being” who’s made even more enemies in Albany than her notoriously vindictive boss, sources who know her told The Post.

Melissa DeRosa, whose job as secretary to the governor makes her the state’s most powerful non-elected official, was described by one former Executive Chamber insider as “the worst person I have ever worked for in my entire professional career.”

“She is a ruthless, heartless, evil human being who will rip your heart out in order to get what she wants,” the source said.

“She doesn’t have time for niceties. She doesn’t have time to get to know you as a person. You are either an individual who gets something done for her — or you’re in her way.”

The source also said that the “toxic” and “abusive” work environment described in Attorney General Letitia James’ devastating report on the sexual harassment allegations against Cuomo “starts with [DeRosa] and it trickles down.”

A former Cuomo staffer said of DeRosa, “I would have to think long and hard to find anyone who would say nice things about her.”

“She doesn’t treat people well. She would dress people down for no reason or over minor stuff,” the ex-colleague said.

“Every problem is considered an equal crisis. Everything is treated as over the top. As a government, that’s not sustainable.”

The source added: “She is now going to experience the fruits of that.”

Another source close to the governor’s office said: “The only person with more enemies than Andy is Melissa.”

DeRosa’s outsize influence among Cuomo’s cronies is illustrated by the fact that James’ 168-page report mentions both her and the governor by name the same number of times — 187 — even though Cuomo’s name appears in the title and twice more in the table of contents.

One section addresses Cuomo’s alleged penchant for referring to DeRosa, 38, and other female loyalists as his office’s “mean girls” — with DeRosa apparently emerging as the meanest of the bunch.

Among other things, investigators found she tried to discredit former Cuomo aide Lindsey Boylan — the first woman to go public with sexual harassment allegations against the three-term Democrat — by admittedly leaking complaints from her personnel file to reporters.

DeRosa justified the move because Boylan’s tweets about the governor — which included calling him “one of the biggest abusers of all time — had grown “more and more escalating,” according to the report.

DeRosa also had a hand in circulating a proposed op-ed drafted by Cuomo that included “personal and professional attacks” on Boylan before it was abandoned for engaging in “victim shaming,” the report said.

Boylan — one of 11 women whose allegations against Cuomo are detailed in the report — plans to file a retaliation suit against him and his advisers, her lawyer has said.

DeRosa further admitted yelling at an editor of the Albany Times Union while successfully trying to kill a story about the assignment of a female state trooper to Cuomo’s security detail after just two years on the job, instead of the requisite three.

The unidentified trooper — who Cuomo selected as one of his bodyguards after briefly meeting her — is now among his accusers and told investigators he subjected her to what the report calls “unwelcome touching” and “offensive comments.”

Last year, DeRosa’s ferocious dedication to Cuomo destroyed her close friendship with Rep. Elise Stefanik (R-Glens Falls), with whom she’d been pals since they both attended the Albany Academy for Girls, a private school where they served together on the student council.

Shortly after Stefanik spoke out against Cuomo’s plan to seize ventilators from upstate hospitals and transfer them to New York City amid the first wave of the COVID-19 pandemic, she got a call from DeRosa on her personal cellphone.

Furious, DeRosa “screamed” at and “bullied” Stefanik in a failed attempt to make her walk back her comments and the two women never spoke again, a source familiar with the matter told The Post in May.

Stefanik confirmed that account in a brutal series of tweets Wednesday that addressed DeRosa’s role in Cuomo’s sexual harassment scandal and called her “an unelected sycophant hack funded by the NY taxpayer.”

“As I said to her in our last conversation…’Your unhinged screaming is an embarrassment,’ ” Stefanik wrote.

“‘Unlike you, my name is actually on the ballot and the door & I work for & serve the people who elect me. Let me be clear, I will never be bullied or threatened by you and I do not now & will never work for you.’”

In addition to the revelations contained in James’ report, a recording exclusively obtained by The Post in February exposed how DeRosa secretly admitted to Democratic lawmakers that Cuomo’s administration withheld the total number of nursing home residents killed by COVID-19.

Following that scoop, the FBI and the Brooklyn US Attorney’s Office opened an investigation into the cover-up and the administration’s handling of nursing homes amid the pandemic.

In a statement to The Post, DeRosa did not comment on the matter but instead accused a Post reporter of being “obsessed” with her.

Cuomo spokesman Rich Azzopardi said, “No amount of cheap, gutless character assassination by anonymous sources with an ax to grind will erase the good Melissa has done for the people of New York.”

“Because of her hard work, the minimum wage is $15, [in-vitro fretilization] is covered by insurance and paid family leave, free public college tuition and gestational surrogacy, among other key reforms, are the law of the land.”