A firefighter was seriously hurt and two civilians left with minor injuries during an early-morning blaze in a Queens home, the FDNY said.

The fire broke out just after 5 a.m. on the second floor of the building on 85th Street near 88th Road in Woodhaven, officials said.

Twenty-five units, with 106 firefighters, battled the blaze until it was placed under control around 6:30 a.m., according to the fire department.

One firefighter is listed in serious but stable condition, and two civilians sustained minor injuries, officials said.

All three went to North Shore University Hospital.

The cause of the fire is under investigation.