At least four people were injured — one critically — in a fire at a Bronx high-rise on Wednesday night, authorities said.

The blaze broke out at about 6 p.m. in a 17-story apartment building on East 169th Street in the Morrisania section, according to the FDNY.

Two residents and two firefighters were injured from the fire, officials said.

One of the residents was critically injured, while the other three suffered minor injuries.