The director of operations for the Clooney Foundation for Justice was busted for drunk driving through the Holland Tunnel — and then mouthed off to the cops, The Post has learned.

Brenna Sermoneta, 41, of Newark, was pulled over by Port Authority police on Tuesday night after she was spotted erratically braking and swerving her Toyota Rav 4 inside the tunnel, cops said.

Sermoneta was pulled over at 14th Street and Jersey Avenue in Jersey City and failed a sobriety test, according to police.

As officers arrested her, a belligerent Sermoneta shouted, “Get the f—king cuffs off me!” law enforcement sources said.

Her blood alcohol concentration was more than double the legal limit, police said.

She was charged with DWI, reckless driving and issued a traffic summons.

Sermoneta has worked for the nonprofit organization co-founded by George and Amal Clooney since March, according to her LinkedIn profile.