The retrial of the accused killer of slain Queens jogger Karina Vetrano opened Monday — with prosecutors right out of the gate trying to do damage control on two possible hang-ups that stymied the first jury.

Four months after the controversial mistrial, Assistant District Attorney Brad Leventhal tried to hammer home that suspect Chanel Lewis gave a valid video confession to the heinous crime and that there is enough DNA evidence to convict him of it.

DNA from “male donor A was on [Vetrano’s] phone, male donor A was on her neck, male donor A was likely underneath her fingernails. Science had identified Karina’s killer. That killer was male donor A,” Leventhal told the jurors — adding that Lewis’s DNA profile matches that of “male donor A.’’

“The chances of [Lewis’s DNA] profile ever being seen again is 1 of out 6.8 trillion. The equivalent of 90 planet Earths,” the prosecutor said.

Leventhal also said Lewis confessed twice on videotape to the murder, first to detectives and later to prosecutors.

Lewis told one detective that he hadn’t known Vetrano but randomly crossed paths with her as she was running. Minutes earlier, he had angrily left his home because his neighbors were being noisy, he said.

“When he saw her, he saw red, and he just lost it,’’ Leventhal said, recounting what Lewis told detectives. “And he attacked her, and he beat her, and he punched her, and he broke her teeth, and he strangled her.”

Leventhal noted that Karina’s father usually went running with her, but the day of her death, he decided not to.

Karina assured him, “I’ll be OK,’ ” the ADA said. “Little did she know, little could she know, that nothing would ever be OK again.”

Lewis, dressed in a dark gray suit and bow tie, kept a blank stare on his face, looking distracted, as Leventhal addressed the jury.

Beforehand, Vetrano’s mother, who is set to testify for the first time, seemed to be meditating in her seat, holding her hands by her side with their palms up and her eyes closed.

Lewis’s previous trial ended in a hung jury in November after just a day of deliberations, during which jurors had asked to review the DNA evidence and Lewis’s confession.

Lewis’s lawyers say the confession was coerced and that the DNA evidence is shoddy.

Jurors on the first jury told The Post that they had wanted to continue weighing the case before the judge pulled the plug.

A different judge is handling Lewis’s retrial.

Lewis’s camp was set to give its opening statement Monday afternoon.