A man was fatally shot inside an East Harlem bodega on Thursday night, police said.

The 49-year-old victim was arguing with another man at 8:25 p.m. inside La Paloma Candy and Grocery on Lexington Avenue near 116th Street, authorities said.

That’s when the killer pulled out a gun and shot the victim in the head before fleeing, cops said.

The man was rushed to St. Luke’s Hospital where he died shortly after midnight, officials said.