A man was killed at one of the Big Apple’s most notorious homeless shelters on Friday, a brutal attack that follows a spate of violent crimes at city run facilities.

The 56-year-old man was discovered laying on a bed in a pool of blood — with his neck sliced and wrapped in wire — inside a room at the Bellevue Men’s Shelter on East 30th Street and First Avenue at 8:25 a.m., police sources said.

“There was quite a bit of blood. If you look at the room, you look at the body, there was a struggle,” NYPD Assistant Chief William Aubry said.

The man, whose name was not released Friday, shared the room with two other residents, who were wanted by police for questioning Friday, police sources said.

One shelter resident was spotted with blood on his hands after the incident, law enforcement sources said.

Cops, who had no motive Friday, are seeking information from the 67 residents who live in the shelter, police sources said.

The shelter made headlines last year for housing dozens of sex offenders, without informing public.

The de Blasio administration claimed to have cleared it of sex fiends after a resident of the shelter, Rodney Stover, 49 ,allegedly raped a woman in a bathroom of the nearby bar Patron.

In February, Gov. Cuomo demanded police probe an alleged “gang rape” at the shelter and several more violent attacks have broken out since.

Shelter residents told The Post they are scared.

“You have to sleep with one eye open around here,” one person said.

So far this year there have been two assaults on staff members at the Bellevue Men’s Shelter, officials said.

City Human Resources Commissioner Steven Banks said Friday that the NYPD is conducting a “review of the security and safety needs” at the shelter.

A Department of Homeless Services spokeswoman said in a statement, “Our thoughts and prayers go out to the family of the victim. We will have more details about the case when the NYPD investigation is completed.”

“The City is committed to improving shelter safety, which is why we have the NYPD doing a complete review and training DHS peace officers who provide security.”

Friday’s death follows a spate of violent crimes at city homeless facilities.

On Thursday, a man staying at the Skyway Men’s Shelter on the Upper West Side was brutally attacked during an argument.

Mike Oshinowo, 32, smashed a glass bottle over his roommate’s head and slashed the victim with a razor blade, leaving him with a deep cut under the right eye, cops said.

In January, Deven Black, 62, a homeless former middle-school librarian was found nearly decapitated at the Boulevard Homeless Shelter in East Harlem.

Additional reporting by Sarah Trefethen