A man opened fire in the lobby of a Lower East Side Holiday Inn early Wednesday, cops said. 

The suspect and an employee were squabbling about a room inside the hotel on Delancey Street near Suffolk Street just before 12:30 a.m., police said. 

The man then went outside, pulled out a gun and fired it into the lobby, cops said. No one was struck. 

The shooter took off after the incident and was still on the loose later in the morning.