Two men robbed a man at gunpoint on the Upper East Side before one of them held up a yellow-cab driver a short time later, police sources said Monday.

The thugs first held up a 25-year-old man on East 78th Street near First Avenue at around 3:45 a.m. Sunday, taking his backpack, cellphone, wallet and jewelry.

The two then fled west on 78th and likely split up before one of them came upon a cabby sitting in his car parked near Madison Avenue at around 4 a.m., cops said.

The thief ran up to the window and said, “Give me what you have!” He made off with $160.

Neither of the victims was injured.