A man stabbed his estranged wife to death as she screamed, “Please stop!” — and then killed himself — Monday morning in The Bronx, police sources said.

The couple’s teenage son heard his mother’s desperate pleas through the bedroom door at her home and kicked it in, only to find them both dead, sources said.

Alejandro Uribe, 41, wasn’t supposed to be near his wife, Nadia Saavedra, 34, after she separated from him in January.