A motorcyclist and his passenger were left with serious injuries after a suspected drunk driver slammed into them in Harlem late Sunday, cops said.

The driver and his passenger, both 23, were riding north on Adam Clayton Powell Jr. Boulevard near West 116th Street around 10 p.m. when a Volkswagen sedan driver — heading south on the same avenue — turned onto West 116th Street, police said.

In the process, the Volkswagen driver struck the motorcycle, cops said.

The motorcyclist was taken to Harlem Hospital and the woman to Mount Sinai Morningside, both in serious condition, police said.

The Volkswagen driver, also 23, was taken into custody on suspicion of drunk driving.

Charges were pending Monday morning.