A wrong-way motorcyclist killed his passenger when he hit a speed bump and flung the woman nearly 30 feet down the road early Thursday in East Harlem, police said.

Antwane Johnson, 42, of Brooklyn was riding a black 2004 Harley Davidson against traffic on East 110th Street between First and Second Avenues around 4:30 a.m. when he hit the bump and lost control of the bike, sending him and his passenger flying toward the pavement, police said.

The passenger, 28, who was wearing a helmet and whose name hasn’t been released, was pronounced dead at the scene, cops said.

Johnson was taken to an area hospital in stable condition and later charged with aggravated unlicensed operation of a motor vehicle, police said.

George James, a local building super, was sleeping when the impact of the crash woke him up, he told The Post.

“I saw a lady lying on the street. She was on her stomach. Her head was on the ground … She had on a black helmet. There was no movement,” said James, 52.

James saw the driver of the bike about 30 feet away, bleeding from his feet, with no helmet on.

“He was yelling and screaming … ‘Oh God!’” James recalled.

The woman’s body was removed from the scene about two and a half hours after the crash.

Additional reporting by Gabrielle Fonrouge