The Second Avenue Subway is a gold mine for Upper East Side homeowners. Just ask the MTA.

Yes, residents currently get displaced rats, deafening blasts and drill-induced dust storms — but nearby real estate will prove to be one of the best investments in town, insists Michael Horodniceanu, who is spearheading the long-delayed project.

“When this is done, anyone who bought cheap on Second Avenue will get a great return,” he predicted yesterday at a New York Law School breakfast.

And the real-estate firm Stribling & Associates agrees.

“They will do very well,” said Stribling VP Gloria Sheldon.