The New York City Heath Department can continue enforcing its vaccination mandate to combat the measles outbreak terrorizing swaths of Brooklyn, an appeals court has ruled.

The Appellate Division, Second Department on Monday declined to hear arguments on the issue, following an April 18 ruling in which a lower court shot down an attempt by a group of parents to challenge the emergency order requiring that those living in certain Williamsburg ZIP codes receive the measles vaccine.

The panel’s decision came just hours after health officials with the US Centers for Disease Control and Prevention reported that the number of measles cases across the US have hit a 25-year high.

A lawyer for the parents, Robert Krakow, did not immediately return a message.

“As New York City does everything it can to end the measles outbreak, I am thankful that the Appellate Division has denied a request for a temporary restraining order,” said Deputy Mayor for Health and Human Services Herminia Palacio, who enacted the order. “Vaccination is the only way to end this outbreak. We are confident our emergency order was based on solid public health and legal ground, and we will continue to enforce our mandatory vaccination order. Measles represents a serious public health risk and deserves an appropriate response.”