Two people were stabbed — one fatally — in Manhattan on Saturday night, according to police.

A 40-year-old man was stabbed in the abdomen and a 29-year-old man was stabbed in the chest on West 146th Street and Amsterdam Avenue in Hamilton Heights around 11 p.m., police said.

Both victims were transported to Harlem Hospital.

The 40-year-old was pronounced dead at the hospital and the 29-year-old is recovering, according to police.

One person of interest has been detained for questioning, cops said.