A 43-year-old NYPD officer died of his injuries after being struck by a drunk driver with a suspended license on the Long Island Expressway in Queens early Tuesday, Police Commissioner Dermot Shea said.

Anastasios Tsakos, a 14-year veteranwho was assigned to Highway 3, was the father of a 6-year-old daughter and 3-year-old son, Shea said at a press conference.

The highway officer was investigating a previous accident on the highway in Fresh Meadows around 2 a.m. when he was struck head-on by a 2013 Volkswagen, according to Shea.

Tsakos was taken to NewYork-Presbyterian Queens, where he died.

The driver of the Volkswagen, Jessica Beauvais of Hempstead, who was driving under the influence and with a suspended license, was apprehended nearby.

Beauvais, 32, was hit with several charges including several felonies — two counts of vehicular manslaughter, reckless endangerment, fleeing an officer in a motor vehicle, leaving an accident resulting in death, aggravated unlicensed operator, and aggravated unlicensed operator involving alcohol.

She also faces two misdemeanor charges — driving while intoxicated and reckless driving.

Her arraignment was pending later Tuesday.

“We stand here this morning reminded once again in law enforcement, there is no such thing as a routine job,” Shea said. “We stand here devastated and trying to pick up the pieces of what is a shattered home, and a shattered NYPD family.”

Tsakos was directing traffic following a prior accident that happened on the eastbound Long Island Expressway ramp to the Clearview Expressway, Shea said.

He said Beauvais swerved to avoid hitting other vehicles and struck Tsakos as he stood next to his marked police car — before allegedly fleeing the scene.

“I think that when you see the images of [Beauvais’] car and the windshield that is completely shattered, as well as damage to the front of the car, there is no way to not know that you struck an individual,” Shea said. 

The initial, single-car accident the officer was responding to happened around 12:30 a.m., when a vehicle slammed into a utility pole and burst into flames, Shea said.

Police officers scrambled to break the window and pull the three occupants from the fiery wreck, but one passenger did not survive, he said.

Driver Jonathan Espinal, 24, and a front-seat passenger, 19, were both left in critical but stable condition.

Espinal, of Corona, Queens, was arrested and charged with aggravated unlicensed operation of a vehicle and unlicensed operation of a vehicle.

Mayor Bill de Blasio said at the press conference that Tsakos “is dead because he was at an accident where people had driven recklessly also with a suspended license.”

“We see here a horrendous pattern — people doing the wrong thing and other people dead because of it, and one of them a hero officer,” he said.

“A hero officer who did everything right in his life for us. And he is dead because of other people’s negligence,” Hizzoner said, adding that he and Shea had just spent time with the officer’s widow, Irene.

“A few hours ago, she was looking forward to seeing her husband again and now she won’t,” de Blasio said.

Police Benevolent Association President Patrick Lynch said Tsakos was beloved and respected by his colleagues.

“In the police department, there are two compliments that you can give a fellow police officer that top no other,” he said. “He’s a cop’s cop and he’s a good guy. You heard them both in this emergency room.”

Donations for Tsakos’ two children and widow can be sentthrough the Survivors of the Shield, Church Street Station, PO Box 436, New York, NY 10008.