A Bronx man’s marijuana harvest is about to “go up in smoke,” the NYPD said on Twitter.

“A search warrant leads to an illegal grow operation w/ 50lbs of marijuana to go up in smoke #notoregano #morrispark,” the 49th Precinct posted on its Twitter feed Wednesday night.

Cops armed with a search warrant based on an ongoing drug investigation went to Ernest Guttilla’s Morris Park home around 1:30 p.m, police said.

Inside 1723 Fowler Ave., they found 50 pounds of pot, police said. Guttilla, 48, was charged with criminal possession of marijuana, a felony.