One person was killed and four people hurt in a seven-car chain reaction crash early Saturday in Queens, cops said.

The havoc began around 4:15 a.m. when a 29-year-old man driving a 2011 Chevy north on the Van Wyck Expressway near Exit 12 rammed into the side of a 2012 Acura sedan.

The 27-year-old woman behind the wheel of the Acura then lost control and slammed into the dividing median — causing it to flip over to the southbound side of the roadway, where it smashed into a 2015 Jeep SUV, driven by a 48-year-old man.

The domino effect continued when a Ford pick-up truck driven by a 43-year-old man slammed into the overturned Acura, according to police

A 2011 Honda sedan, which was also heading south on the expressway, was then struck by debris from the collisions, cops said.

Meanwhile, the Chevy continued north on the expressway, where it ultimately struck a 2012 Toyota SUV and a 2005 BMW, according to police.

Jairo Castano, 38, of Brooklyn, was riding in the Acura when it flipped over. He was pronounced dead at the scene.

Another man who was riding in the Chevy was also hurt. The 38-year-old was taken to New York Presbyterian Hospital in Queens in stable condition.

The drivers of the Honda, Toyota and BMW refused medical attention.

No arrests had been made.

About an hour earlier in nearby Corona, an NYPD patrol car was also caught in a smash-up.

Two officers were driving near 102nd Street and 45th Avenue around 3:20 a.m. when their vehicle was T-boned by a man driving an Acura MDX.

The Acura driver, 25, initially ran from the scene but was later taken into custody, police said. Charges were pending.

The officers were taken to Elmhurst Hospital in stable condition.