Lynn Samuels, longtime doyenne of New York’s talk-radio airwaves, died of a heart attack over the weekend. She was 69.

An unabashed liberal, Samuels mixed searing political commentary with humor, sarcasm and at times profane observations about living in the Big Apple, attracting a loyal following over more than three decades on the air.

Broadcast on SiriusXM satellite radio from her Woodside, Queens, apartment, her distinctive voice — raspy with elongated vowels — instantly established her as a native New Yorker.

When she missed her broadcast Saturday morning, SiriusXM called the police, who found her body.

Samuels once quipped on air, “I avoid my neighbors — luckily, my building has two exits.”