After 25 assassination attempts on him and more than a decade behind bars, the hard life may finally be catching up to reputed Mafia boss Joseph “Skinny Joey” Merlino.

A Manhattan federal judge has agreed to postpone the alleged mobster’s racketeering trial here for a week because Merlino, 55, had to be hospitalized in a Florida hospital earlier this week for two heart blockages.

The tough guy was suffering from chest pains, shortness of breath and spasms, his lawyer said. The hospital performed a catheterization on him.

Merlino was supposed to head to trial here next Tuesday, but the case has now been put off till Jan. 22.

Merlino has been free on $5 million bond and living in Boca.