Six people were injured in a 27-vehicle crash that shut down all southbound lanes of the Henry Hudson Parkway on Wednesday night, officials and sources said.

The chain-reaction crash occurred in snowy conditions on the parkway near West 181 Street in Upper Manhattan at about 6:10 p.m., authorities said.

Four of the injuries were considered serious, but not life threatening, while two were minor, the FDNY said. All of the victims were hospitalized.

Videos posted to the Citizen app show a line of cars at a standstill on the parkway that connects Manhattan and The Bronx.