Archbishop Timothy Cardinal Dolan held Palm Sunday Mass from a near-empty St. Patrick’s Cathedral after it was closed to the public because of what he called “this vicious coronavirus.”

“We miss you, very much, being with us physically,” Dolan said soon after the opening of the 10 a.m. Mass which kicks off Holy Week leading to Easter.

“But we make the best of this, and we know that Jesus is with us,” he said.

The service was instead live-streamed on the Cathedral’s website — which also allowed worshippers to leave virtual palms — with Dolan praising all of those who helped make sure his message could still reach “so many at home.”

The Archbishop warned that panic over the deadly pandemic could cause people to turn against their faith — comparing it to the rejection of Christ before his crucifixion.

“We find ourselves now in a Good Friday moment, with this vicious coronavirus,” Dolan said.

“We’re apprehensive, we’re anxious, we’re alone. Many feel by themselves and so many attacked by the virus with families and friends so worried and brave health care workers tending to them.

“And — I hate to say it — we may be tempted to lose trust in the one we believe to be our Lord, our savior, the way, the truth and the life,” he said.

“We may be lured to doubt him, even to abandon him.

“We may be led to remain in this Good Friday moment of rejecting him, mocking him, believing that the darkness and despair and death have the last word — instead of ‘the word.’ The one who is our life and our light. Jesus my Lord my God my all.

“In this palm Sunday we acclaim, ‘None of that!’ We are not fairweather friends of Jesus — we are faithful, not fickle, we hope, not holler, ‘Away with him!'” he said as he stood alone at the pulpit.

The Archbishop wrote in The Post that “Passover and Easter will be especially meaningful this week.”

He said “millions of Jews and Christians recall with awe that our God is Lord of life and death, and can bring good out of evil, healing from illness, life from death.”