A 22-year-old Washington Heights woman, her mom and grandmother were all killed yesterday in a devastating car wreck in eastern North Carolina as the women and five other relatives were driving home from Disney World, state police said.

Trooper G.G. Barnes of the North Carolina Highway Patrol said the family’s SUV blew a tire on northbound I-95 at 4:20 p.m.

“The driver lost control of the vehicle and it overturned,” he told The Post, adding that the two older women weren’t wearing seatbelts and were tossed from the vehicle.

He said the SUV rolled over and came to a rest off the highway.

Barnes identified the victims as Rosanny Marte, 22; Angela Marte, 46; and Rosa Marte, 71.

Five other family members in the SUV — including the husbands of Angela and Rosa Marte, and Angela’s two other children and nephew — remained hospitalized early today with non-life-threatening injuries, he said.

Barnes said the family all lived at the same West 171st Street address.