Two children were injured when a fire raged through a home in Queens on Friday morning, officials said.

The blaze was ignited inside a residence in Flushing just after midnight and the two youngsters needed to be saved from a second-floor bedroom, according to police.

A total of 50 firefighters responded and the blaze was extinguished by 12:45 a.m., cops said.

Both of the children were transported to Elmhurst Hospital in serious condition.