Two people were killed and one was seriously hurt when they were struck by vehicles in Brooklyn and Manhattan, cops said Friday.

Most recently, a 43-year-old man was walking in the crosswalk against the light at Grand and Waterbury streets in East Williamsburg around 11:40 p.m. Thursday when a driver rammed into him, police said.

He was taken to Elmhurst Hospital Center in critical condition, with head trauma.

Last Saturday, Kathie Coblentz, 73, died just steps from her home after she was struck by a 2009 Honda Odyssey Minivan, which pulled out of an underground parking garage as she was walking on West 58th Street near Eighth Avenue in Manhattan around 2:10 p.m., cops revealed Friday.

Coblentz fell backwards and struck her head on the pavement, according to police.

She was taken to Mount Sinai Morningside, where she was pronounced dead.

The 31-year-old driver, who was unharmed, stayed on scene and was not immediately arrested.

A homeless man also died this week, nearly two months after he was rammed by a hit-and-run driver while crossing the street in Prospect Heights, cops said.

Michael Williams, 45, was crossing Atlantic Avenue southbound at the Bedford Avenue intersection just after 11 p.m. Feb. 17 when he was hit by an unknown vehicle, police said.

Police found him lying in the middle of the street with trauma to his head and torso.

He was taken to the Kings County Hospital Center, where he was pronounced dead Monday, cops said.

The driver took off and has not been caught, cops said.