A man was struck and killed by a hit-and-run driver in Queens on Wednesday night, authorities said.

The 45-year-old victim was in the roadway on 21st Street near 30th Road when he was hit by a dark-colored sedan around 11 p.m.

The driver left the man for dead and sped off after the crash, cops said.

First responders rushed the man to Elmhurst Hospital, where he was pronounced dead.

Police are still looking for the driver.

Hours later, a man was killed while walking down a busy Bronx highway, officials said.

The man was walking along the northbound side of the Major Deegan Expressway near East 138th Street when he was struck by a Nissan 370Z around 4:20 a.m.

The 28-year-old driver who struck the man remained at the scene and has not been charged with a crime.

The victim was taken to Lincoln Hospital, where he was pronounced dead.

It was not immediately clear why the pedestrian was walking on the highway.